The Public Health Service of Amsterdam (GGD Amsterdam) will host a transformative South-to-South Learning Exchange, uniting Caribbean public health leaders, clinicians, and civil society advocates with Dutch experts to advance HIV prevention and care for priority groups, from 31 March to 4 April, 2025. Supported by The Global Fund, PANCAP, and the Pan American Health Organization (PAHO), this immersive event aims to strengthen HIV and sexually transmitted infection (STI) prevention strategies across the Caribbean by fostering knowledge-sharing, innovation, and cross-regional partnerships.