Summary

The analysis highlights that evidence is evolving that protease inhibitors developed for the treatment of HIV, both lopinavir and darunavir boosted by ritonavir or cobicistat, are not efficacious against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vivo.2, 3, 4. Therefore, antiretroviral combinations should not be changed in an attempt to treat SARS-CoV-2 infection, because neither drug combination is a first-line choice in most guidelines for HIV and changing treatment could lead to increased rates of adverse events.